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Risk Factors for Leaky Gut Syndrome You Should Know

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Leaky gut syndrome is not well understood by modern medical practitioners. But this condition can wreak havoc in your body, and it’s definitely something you want to avoid.

Also known as increased intestinal permeability, leaky gut syndrome (LGS) is a condition that begins in the small intestine, where nutrients from food are absorbed by microscopic pores that cover the intestinal lining.

These pores regulate what enters the bloodstream. But when one suffers from leaky gut, the gaps in the intestinal lining widen. This causes food particles and toxins that should remain in the small intestine to enter the bloodstream.


leaky gut syndrome diagram

The immune system identifies these food particles and toxins as invaders and attacks them, along with healthy cells. This triggers the immune system into action, causing inflammation that can lead to a long and varied list of symptoms, including joint pain, mood issues, acne, psoriasis and fatigue, to name a few.

Anyone can suffer from leaky gut syndrome, but certain risk factors make you more vulnerable to this mysterious condition.

risk factors for leaky gut syndrome


Here are the key factors that raise your risk of having a leaky gut.

1. Poor Diet

The most common risk factor for leaky gut syndrome is a poor diet. There are several components in food that can damage the intestinal lining, leading to inflammation.

poor diet increases risk for leaky gut

One popular culprit is the proteins found in unsprouted grains, sugar, genetically modified foods (GMOs) and conventional dairy products. These foods also contain a good amount of nutrient blockers called phytates and lectins.

For instance, the sugar-binding proteins called lectins act as a natural defense system for plants. They protect plants from outside invaders like mold and parasites, but they are harmful for the human body. Lectins attach to the digestive lining, cause damage to your gut and lead to inflammation.

Also, high amounts of refined sugars, processed foods, preservatives, refined flours and flavorings introduce high amounts of chemicals and toxins into the body that can ultimately cause inflammation.


2. Chronic Stress

Chronic stress is one of the major causes as well as risk factors for leaky gut syndrome.

Stress not only signals bacteria to multiply and mutate, it also affects the functionality of the digestive system and suppresses the immune system.

chronic stress increases risk of leaky gut syndrome

A weakened immune system cannot maintain the balance of pathogens in the gut. This can lead to an overall increase in inflammation including in the gut, which in turn alters intestinal physiological function, increases gut permeability and causes inflammation.

A 2011 study published in the Journal of Physiology and Pharmacology highlights the link between stress and gut health. The study shows that the major effects of stress on gut physiology include alterations in gastrointestinal motility, increased visceral perception, changes in gastrointestinal secretion and increased intestinal permeability.

3. Medications

Any painkiller medication (prescribed or over-the-counter) taken in excess can irritate the intestinal lining and reduce the mucosal level (a membrane that produces mucus on the intestinal lining as a natural protective measure). Over time, this can lead to inflammation and an increase in permeability.

certain medications increase risk of leaky gut

Even nonsteroidal anti-inflammatory drugs (NSAIDs) can damage the gut. These medicines kill good bacteria and often create an imbalance in gut bacteria. When bad bacteria take over the good ones, it leads to inflammation and ultimately LGS.

Also, long-term use of oral contraceptive pills increases a woman’s risk.

Occasional use of these medicines is typically harmless, but long-term or excessive use increases your susceptibility to LGS.

4. Excess Toxins

The chemicals and toxins that you come in contact with on a daily basis is another worst offender for causing leaky gut.

excess toxins increase risk for leaky gut syndrome

If your natural detoxification process is not working properly, toxins build up in the body.

Over time, these toxins can irritate the intestinal lining and lead to inflammation as well as weak immunity. The constant inflammation and low immune system activity together causes more permeability in the gut wall.

Risk Factors for Leaky Gut Syndrome You Should Know was last modified: January 28th, 2017 by Top10HomeRemedies
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